Introductory notes to the NIBR 2004 presentation
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SLIDE 1 (TITLE)
I'm going to talk today about some of the results of the modeling method
that I have been advancing with Mike Hasselmo at the Laboratory of
Computational Neurophysiology at the Center for Memory and Brain.

SLIDE 3 (OVERVIEW)
In the first part of our work, we focused on determining the importance
and function of brain rhythms, specifically the prominent theta rhythm.
Then, we improved the system architecture to model how a more complete
set of brain regions are involved in task specific deficiencies due to
lesions.
In that, we focused on the importance of converging paths of activity
within prefrontal cortex and on properties of prefrontal network
neuroanatomy that support learning of goal-directed behavior.
And most recently, we applied our prefrontal model to a replication and
explanation of results by Schultz et al. in a primate visual
discimination task that was based on well known experiments by Thorpe
et al. As it happens, our conclusions in that task will be submitted
for publication a few days from now. The results provide an explanation
for very selective activity recorded at individual neurons.

Reminder to mention:
ADP is caused by calcium sensitive cation currents that are induced by
muscarinic receptor activation (Klink and Alonso, 1997).